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Creative Diagnostics offers custom construction services for nanoparticles based drug targeting and delivery system. Targeted drug delivery can overcome the drawbacks of conventional therapeutic drugs, such as poor biodistribution, lack of selectivity and severe side effects.
Nanoparticles drug delivery systems have great advantages including prolonged circulation time, enhanced permeability and retention (EPR) effect, active targeting, and reduced side effects. Furthermore, the unique physicochemical properties of nanoparticles such as optical, magnetic and thermal features enable simultaneous diagnosis and therapy (defined as “theranostics”). For instance, besides serving as drug carrier, iron oxide magnetic nanoparticles can also be used as hyperthermia agents and magnetic resonance imaging (MRI) contrast probes, due to the magnetocaloric effect and high molar relaxivity respectively (Figure 1).
Figure 1 Schematic illustration of cancer diagnosis and therapy with nanoparticles
Creative Diagnostics is proficient in construction of nanoparticles based drug delivery system to meet your unique requirements. Our experienced scientists can optimize your drug pharmacokinetics, targeting and treatment efficacy by tuning nanoparticle size, shape and surface properties.
Our Technical Data include:
• Hydrodynamic size and zeta-potential (before and after drug loading)
• TEM image of the particles (before and after conjugation)
• Drug loading efficiency
Ahmed N., Fessi H. and Elaissari A. Theranostic applications of nanoparticles in cancer. Drug Discovery Today. 2012, 17, 928-934.