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The Absolute Mag™ Lanthanide-Based Magnetic Particles is a kind of super-paramagnetic magnetic particles formed by the reaction of a strong lanthanide element (Ln) mono-electronic oxidant with Massart magnetite under high-power ultrasonic irradiation. These particles have a γ-Fe2O3 core and are positively charged, hydrophilic, and not easy to aggregate in aqueous suspensions/ferrofluids due to electrostatic repulsion. Since the lanthanide elements have a characteristic oxidation state of +3 valence, it is readily reacts with the Lewis base, therefore, the particles can also be further functionalization.
CAN-Fe2O3 Nanoparticles are especially recommended here for innovatively gene silencing application. CAN-Fe2O3 Nanoparticles are produced with two critical reaction material, Massart magnetite (Fe3O4) NPs and Ceric Ammonium Nitrate [CAN, CeIV(NH4)2(NO3)6], and Fe3O4 is converted into Fe2O3 as particle core after reaction while CAN encloses a layer of [CeLn]3+/4+ cations on the outer surface of the core. The shell [CeLn]3+/4+ complexes can bind and/or chelate with Lewis base mono and multi-dentate ligands including chelating polymers like a poly-cationic endosomolytic 25 kDa branched b-PEI polymer to create PEI25-CAN- Fe2O3, which enables siRNA/microRNA electrostatic capture and stabilization, cell delivery, and gene silencing.
|Cat.No||Description||Surface||ParticleSize||Concentration||Unit Size||Add to basket|
|CAN-FN01||CAN-Fe2O3 Nanoparticles||N/A||40 nm||3.23 mg/mL||10 mg|
|CAN-FN02||CAN-Fe2O3 Nanoparticles||Alginic acid 120-190 KDa/b-25 KDa-PEI||70 nm||1.3 mg/mL||10 mg|
|CAN-FN03||CAN-Fe2O3 Nanoparticles||Hyaluronic acid 15-30KDa/ b-25 KDa-PEI||96.3 nm||2.075 mg/mL||10 mg|
|CAN-FN04||CAN-Fe2O3 Nanoparticles||Oxidized branched 25 KDa-PEI||124.1 nm||2.8 mg/mL||10 mg|
|CAN-FN05||CAN-Fe2O3 Nanoparticles||Branched 25 KDa PEI||85.9 nm||1.3 mg/mL||10 mg|