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Lanthanide-Based Magnetic Particles
The Absolute Mag™ Lanthanide-Based Magnetic Particles is a kind of super-paramagnetic magnetic particles formed by the reaction of a strong lanthanide element (Ln) mono-electronic oxidant with Massart magnetite under high-power ultrasonic irradiation. These particles have a γ-Fe2O3 core and are positively charged, hydrophilic, and not easy to aggregate in aqueous suspensions/ferrofluids due to electrostatic repulsion. Since the lanthanide elements have a characteristic oxidation state of +3 valence, it is readily reacts with the Lewis base, therefore, the particles can also be further functionalization.
CAN-Fe2O3 Nanoparticles are especially recommended here for innovatively gene silencing application. CAN-Fe2O3 Nanoparticles are produced with two critical reaction material, Massart magnetite (Fe3O4) NPs and Ceric Ammonium Nitrate [CAN, CeIV(NH4)2(NO3)6], and Fe3O4 is converted into Fe2O3 as particle core after reaction while CAN encloses a layer of [CeLn]3+/4+ cations on the outer surface of the core. The shell [CeLn]3+/4+ complexes can bind and/or chelate with Lewis base mono and multi-dentate ligands including chelating polymers like a poly-cationic endosomolytic 25 kDa branched b-PEI polymer to create PEI25-CAN- Fe2O3, which enables siRNA/microRNA electrostatic capture and stabilization, cell delivery, and gene silencing.
Features:
- Not easy aggregate in aqueous suspensions due to electrostatic repulsion.
- Ce3/4+ cation coordinative chemistries and shell COOH provides a novel orthogonal surface chemistry/engineering for drugs, polymers, etc.
- Innovatively for gene silencing applications with the existence PEI25 (together with MRI tracking features).
| Cat.No | Description | Surface | ParticleSize | Concentration | Unit Size | Add to basket |
|---|---|---|---|---|---|---|
| CAN-FN01 | CAN-Fe2O3 Nanoparticles | N/A | 40 nm | 3.23 mg/mL | 10 mg |  |
| CAN-FN02 | CAN-Fe2O3 Nanoparticles | Alginic acid 120-190 KDa/b-25 KDa-PEI | 70 nm | 1.3 mg/mL | 10 mg | |
| CAN-FN03 | CAN-Fe2O3 Nanoparticles | Hyaluronic acid 15-30KDa/ b-25 KDa-PEI | 96.3 nm | 2.075 mg/mL | 10 mg | |
| CAN-FN04 | CAN-Fe2O3 Nanoparticles | Oxidized branched 25 KDa-PEI | 124.1 nm | 2.8 mg/mL | 10 mg | |
| CAN-FN05 | CAN-Fe2O3 Nanoparticles | Branched 25 KDa PEI | 85.9 nm | 1.3 mg/mL | 10 mg | |
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