The Absolute Mag™ Lanthanide-Based Magnetic Particles is a kind of super-paramagnetic magnetic particles formed by the reaction of a strong lanthanide element (L_n) mono-electronic oxidant with Massart magnetite under high-power ultrasonic irradiation. These particles have a γ-Fe₂O₃ core and are positively charged, hydrophilic, and not easy to aggregate in aqueous suspensions/ferrofluids due to electrostatic repulsion. Since the lanthanide elements have a characteristic oxidation state of +3 valence, it is readily reacts with the Lewis base, therefore, the particles can also be further functionalization.

CAN-Fe₂O₃ Nanoparticles are especially recommended here for innovatively gene silencing application. CAN-Fe₂O₃ Nanoparticles are produced with two critical reaction material, Massart magnetite (Fe₃O₄) NPs and Ceric Ammonium Nitrate [CAN, CeIV(NH₄)₂(NO₃)₆], and Fe₃O₄ is converted into Fe₂O₃ as particle core after reaction while CAN encloses a layer of [CeL_n]^3+/4+ cations on the outer surface of the core. The shell [CeL_n]^3+/4+ complexes can bind and/or chelate with Lewis base mono and multi-dentate ligands including chelating polymers like a poly-cationic endosomolytic 25 kDa branched b-PEI polymer to create PEI25-CAN- Fe₂O₃, which enables siRNA/microRNA electrostatic capture and stabilization, cell delivery, and gene silencing.

Features:

• Not easy aggregate in aqueous suspensions due to electrostatic repulsion.
• Ce^3/4+ cation coordinative chemistries and shell COOH provides a novel orthogonal surface chemistry/engineering for drugs, polymers, etc.
• Innovatively for gene silencing applications with the existence PEI25 (together with MRI tracking features).

Cat.No	Description	Surface	ParticleSize	Concentration	Unit Size	Add to basket
CAN-FN01	CAN-Fe2O3 Nanoparticles	N/A	40 nm	3.23 mg/mL	10 mg
CAN-FN02	CAN-Fe2O3 Nanoparticles	Alginic acid 120-190 KDa/b-25 KDa-PEI	70 nm	1.3 mg/mL	10 mg
CAN-FN03	CAN-Fe2O3 Nanoparticles	Hyaluronic acid 15-30KDa/ b-25 KDa-PEI	96.3 nm	2.075 mg/mL	10 mg
CAN-FN04	CAN-Fe2O3 Nanoparticles	Oxidized branched 25 KDa-PEI	124.1 nm	2.8 mg/mL	10 mg
CAN-FN05	CAN-Fe2O3 Nanoparticles	Branched 25 KDa PEI	85.9 nm	1.3 mg/mL	10 mg

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