Creative Diagnostics provides Fluorescent Gold Nanoparticles (AuNPs) labeled with various fluorophores for multimodal imaging by dark-field scattering, fluorescence, as well as electron microscopy. The fluorophore labeled gold nanoparticles exhibit both high absorptions and scattering from gold nanoparticle as well as enhanced fluorescence from the attached fluorophores. Gold nanoparticles significant enhance the fluorescent signal and quantum yield of fluorophores based on the metal-enhanced fluorescence (MEF) effect.

These nanoparticles are available with the following fluorophores, IRDye 800, Alexa Fluor 750, Alexa Fluor 680, Cy5.5, Alexa Fluor 647, Cy5, Alexa Fluor 633, Alexa Fluor 594, Texas Red, Alexa Fluor 546, Alexa Fluor 555, FITC, Alexa Fluor 488.

Various active groups or ligands can be chosen according to customer's need, including amine, biotin, carboxyl, maleimide, methyl, neutravidin, NHS, streptavidin, MUTAB, protein A and secondary antibodies. PEG or proprietary polymer is used as covalent polymer bridge to the most popular in vitro terminations. For in vivo surface terminations, a proprietary long circulating polymer would give the gold nanoparticles ultra-long circulation time.

The fluorophore labeled AuNPs are supplied in distilled water, PBS, Tris, Sodium Borate or MES; Other custom buffers are also available on request.

Creative Diagnostics also offers a series of fluorophore labeled AuNPs with specific cellular uptake ligands to promote cellular uptake. These gold nanoparticles are non-toxic, suited for in vivo application.

Custom conjugations are available for special fluorophores, functional surfaces and molecules, such as antibodies, proteins, peptides, lectins, etc.

Please do not hesitate to contact us if you need free consultation and a detailed quotation of your project. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

Applications:

• Dual modal imaging by fluorescence and electron microscopy
• Increased fluorescence signal and higher quantum yield
• Increased stability in a wider pH range
• Lower background and higher signal-to-noise ratios
• Multiplex imaging for different targets using different fluorophores

Cat. No.	Description	Diameter	Absorption Max	Surface	Unit Size	Fluorophore	Add to basket
GFL-10	Fluorescent Gold Nanoparticles	10 nm	514-520 nm	Optional	1 mL	√
GFL-100	Fluorescent Gold Nanoparticles	100 nm	558 nm	Optional	1 mL	√
GFL-10-CU	Fluorescent Gold Nanoparticles, Cellular Uptake	10 nm	514-520 nm	Cellular uptake ligand	1 mL	√
GFL-125	Fluorescent Gold Nanoparticles	125 nm	600 nm	Optional	1 mL	√
GFL-15	Fluorescent Gold Nanoparticles	15 nm	514-520 nm	Optional	1 mL	√
GFL-150	Fluorescent Gold Nanoparticles	150 nm	612 nm	Optional	1 mL	√
GFL-15-CU	Fluorescent Gold Nanoparticles, Cellular Uptake	15 nm	514-520 nm	Cellular uptake ligand	1 mL	√
GFL-20	Fluorescent Gold Nanoparticles	20 nm	514-520 nm	Optional	1 mL	√
GFL-200	Fluorescent Gold Nanoparticles	200 nm	N/A	Optional	1 mL	√
GFL-20-CU	Fluorescent Gold Nanoparticles, Cellular Uptake	20 nm	514-520 nm	Cellular uptake ligand	1 mL	√
GFL-25	Fluorescent Gold Nanoparticles	25 nm	514-520 nm	Optional	1 mL	√
GFL-25-CU	Fluorescent Gold Nanoparticles, Cellular Uptake	25 nm	514-520 nm	Cellular uptake ligand	1 mL	√
GFL-30	Fluorescent Gold Nanoparticles	30 nm	523 nm	Optional	1 mL	√
GFL-30-CU	Fluorescent Gold Nanoparticles, Cellular Uptake	30 nm	523 nm	Cellular uptake ligand	1 mL	√
GFL-35	Fluorescent Gold Nanoparticles	35 nm	526 nm	Optional	1 mL	√
GFL-35-CU	Fluorescent Gold Nanoparticles, Cellular Uptake	35 nm	526 nm	Cellular uptake ligand	1 mL	√
GFL-40	Fluorescent Gold Nanoparticles	40 nm	527 nm	Optional	1 mL	√
GFL-40-CU	Fluorescent Gold Nanoparticles, Cellular Uptake	40 nm	527 nm	Cellular uptake ligand	1 mL	√
GFL-45	Fluorescent Gold Nanoparticles	45 nm	529 nm	Optional	1 mL	√
GFL-45-CU	Fluorescent Gold Nanoparticles, Cellular Uptake	45 nm	529 nm	Cellular uptake ligand	1 mL	√

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