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Creative Diagnostics provides magnetic particles functionalized with various terminal active groups for further conjugation of affinity ligands. The conjugation between particles and ligands can be established by direct conjugation, click chemistry, and linker chemistry. In direct conjugation stratagem, magnetic beads surface can be functionalized with amine, carboxyl, sulfhydryl, aldehyde, and active hydrogen functional groups. In “click” chemistry, magnetic beads are functionalized with alkyne to react with azide functionalized ligands under Cu catalyst. Conjugation by linker chemistry offers control over themolecular orientation of bound ligands, which is critical for protecting ligands functionality. Magnetic beads surface functionalized with amine or carboxyl groups can be modified with heterobifunctional linker molecules and further reacted with ligands.