It is\nequivalent to the diameter of natural tissue fibers;<\/li>

With diverse\nforms and a wide range of choices, including nanoparticles<\/a>,\nnanocrystals, nanotubes, nanofibers, nanofilms;<\/li>

The specific\nsurface area is very large and the adsorption performance is good;<\/li>

It has high\nmechanical strength, light weight, and can reduce the squeeze of the wound;<\/li>

Itself can\nbe antibacterial;<\/li>

It can embed\nor load drugs, growth factors, proteins, etc., and play a role of slow release.<\/li><\/ol>\n\n\n\n
The large specific surface area and the porous structure\ncan greatly improve the contact area or probability of the nano dressing with\nthe cells or tissues, so that the nano dressing can easily enter the wound\ntissue cells or stay in the cells to regulate the biological signals, and\npromote the cell growth, proliferation and differentiation before tissue repair\nprocess. Nano dressings also improve the local microenvironment of tissue cell\ngrowth, regulate and optimize the formation of extracellular matrix, promote\ntissue cell regeneration and migration to the wound, and create conditions for\npost-repair tissue remodeling. For more serious tissue defects or injuries that\ncannot be repaired quickly under natural conditions, the application of nano\ndressings to the wound provides a “platform” for the migration and\ncolonization of surrounding normal cells to the defect area, accelerating the\ngrowth of regenerating cells and secretion of the matrix to promote the repair\nof defects. In the treatment of burns, it is necessary to cover a large area of\nwounds with as little therapeutic material as possible to protect the skin and\npromote wound healing. Nano dressings meet this requirement.<\/p>\n\n\n\n
Nano dressings also provide a support for tissue engineered\nskin implants. Wounded skin often loses the epidermal layer that constitutes a\nmechanical barrier. Nanofibers provide good mechanical support while achieving\ntherapeutic effects.<\/p>\n\n\n\n
The chemical drug or bioactive molecule can be embedded in\nthe nano dressing and released into the wound tissue by dissolution of pores or\nmaterials in the dressing. By adjusting the porosity of the nano dressing and\nthe composition and structure of the nanofibers, the release rate of the active\nmolecules can be controlled. The sustained-release property not only avoids the\ntoxicity of local high-concentration drugs, but also ensures the persistence of\nthe drug in the damaged area and the stability of the drug, further promoting\nthe regeneration and repair of damaged cells. Nano dressings can also carry\nadult stem cells and progenitor cells, and continue to release “seed\ncells” to the defect and differentiate them into adult cells, accelerating\nthe regeneration and tissue repair of defective cells.<\/p>\n\n\n\n
The molecular structure of the polymer is diverse (such as\nlinear, star, tree and hyperbranched), and there are many surface binding\nsites, which are easily combined with active molecules. The surface of the\npolymer is modified by functional groups and can be coupled with antibacterial\ndrugs to kill or inhibit various chronic wound-infecting microorganisms such as\nStaphylococcus aureus<\/em>,\nPseudomonas aeruginosa<\/em>\nand Escherichia coli<\/em>.\nPolymer drug conjugates, polymer protein conjugates, polymer micelles and the like\nhave been used as drug carriers for tissue repair and wound care. The\ncomposition of polymer protein growth factor can produce good interfacial\ninteraction with the wound microenvironment, and has important application\nvalue in the field of tissue repair. According to the actual needs of wound\ncare and tissue repair, the best results can be obtained by controlling the\nphysical properties (rheological, hydrophilic), mechanical properties\n(plasticity) of nano-dressings, and introducing active ingredients.<\/p>\n\n\n\n
Nano silver dressing<\/strong><\/p>\n\n\n\n
The ions of various metals have antibacterial action, and\nthe order of antibacterial action is: Ag>Hg>Cu>Cd>Cr> Ni>\nPd>Co>Zn>Fe. However, Hg, Cd, Pd and Cr have residual toxicity to\nhuman body, and ions of Ni, Co and Cu have dyeing effect on objects. In fact,\nthe commonly used metal antibacterial agent is silver antibacterial agent.\nMetallic silver-based external preparations have long been used in a wide range\nof aerobic and anaerobic microbial broad-spectrum antibacterial agents. At low\nconcentrations, silver cations (Ag+) have inhibitory effects on many pathogens\n(bacteria, viruses, eukaryotes, etc.) and are often used in ulcer care and\npublic health.<\/p>\n\n\n\n
Nano-inorganic antibacterial agents, due to quantum effects, small size effects and extremely large specific surface area, have antibacterial effects unmatched by conventional antibacterial agents, while having high safety and long-lasting efficacy. The antibacterial properties of nano-silver are far greater than traditional silver antibacterial agents. Nano-silver<\/a> is widely used as an antibacterial material in medical catheters, surgical instruments, dental antibacterial materials, reproductive health and family planning appliances, and wound dressings. Evaluation of the safety of nano-silver dressings is a key step in its clinical entry. After local or systemic absorption of silver, it may cause cytotoxicity. Increasing the interaction between the medical dressing carrier and the nano-silver and properly controlling the slow release rate of the nano-silver can help to effectively reduce the toxicity of silver. Through the cooperation of the polymer carrier and the nano-silver, the stability of the nano-silver can be controlled, and the scale and morphology of the nano-particle can also be controlled. By using the environmentally sensitive response of the polymer matrix, controlling the change of the dressing structure, realizing the controlled release of nano-silver, reducing the dose of nano-silver acting on the wound surface, and improving the durability of the action and the efficiency of the nano-silver, it can effectively improve the safety of silver-containing materials. <\/p>\n\n\n\n
References
1. Ajay VS, Aditi AS, Gade W N, et al. Nanomaterials: new generation therapeutics in wound healing and tissue re-pair. Curr Nanosci<\/em>, 2010, 6: 577-586.
2. Graham K, Schreuder -Gibson H, Gogins M. Incorporation of electrospon. nanofibers into functional struc-tures. International Nonwoven Technical Conference. Baltimore, USA, 2003.
3. Shon Y s, Choi D. Dendritic functionalization of metal nanoparticles for nanoparticle cored dendrimers. Curr Nanosci<\/em>, 2007, 3: 245-254.
4. BarrientosS, Os, Golinko MS, et al. Growth faclors and eytokines in wound healing. Wound Rep Reg, 2008, 16:585- 601.
5. Vicent M J, Dieudonne L. Crabajo R J,e1 al. Polymer conjugates as therapeutic: future trends, challenges and opportunities. Expert Opin Drug Deliv<\/em>, 2008, 5: 593-614.
Mohan Y M, Vimala K; Thomas V. et al. Controlling of silver nanoparticles structure by hydrogel networks. J Colloid Interface Sci<\/em>, 2010, 342: 73-82. <\/p><\/blockquote>\n\n\n\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
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