{"id":321,"date":"2021-09-24T02:12:07","date_gmt":"2021-09-24T07:12:07","guid":{"rendered":"https:\/\/www.cd-bioparticles.com\/blog\/?p=321"},"modified":"2021-09-24T02:15:22","modified_gmt":"2021-09-24T07:15:22","slug":"contrast-agents-for-near-infrared-fluorescent-imaging","status":"publish","type":"post","link":"https:\/\/www.cd-bioparticles.com\/blog\/nanoparticles\/contrast-agents-for-near-infrared-fluorescent-imaging\/","title":{"rendered":"Contrast Agents for Near-Infrared Fluorescent Imaging"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"439\" src=\"\/blog\/wp-content\/uploads\/2021\/09\/Human-Brain-Imaging-1024x439.png\" alt=\"Human Brain Imaging\" class=\"wp-image-322\" srcset=\"\/blog\/wp-content\/uploads\/2021\/09\/Human-Brain-Imaging-1024x439.png 1024w, \/blog\/wp-content\/uploads\/2021\/09\/Human-Brain-Imaging-300x129.png 300w, \/blog\/wp-content\/uploads\/2021\/09\/Human-Brain-Imaging-768x329.png 768w, \/blog\/wp-content\/uploads\/2021\/09\/Human-Brain-Imaging.png 1269w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>What is near-infrared fluorescence imaging?&nbsp; <\/li><\/ul>\n\n\n\n<p>Near-infrared (NIR) fluorescence is a light wavelength of\n650\u2013950 nm and is generally preferred for <em>in vivo<\/em> fluorescence imaging because of its\ngood tissue penetration and low autofluorescence from 676565adjacent tissues. <a href=\"https:\/\/www.cd-bioparticles.com\/s\/Near-Infrared-NIR-Fluorescent-Imaging_37.html\">NIR<\/a>\nfluorescence imaging is a fast, convenient and non-invasive imaging technique\nfor visualizing deep-tissue structures. <\/p>\n\n\n\n<p>NIR fluorescence imaging can be categorized into\nfluorescence reflectance imaging (FRI) and tomographic fluorescence imaging.\nAdvantageous features of FRI are high spatial resolution, fast, real-time\ndisplay, relatively low cost, portability and ability to multiplex several\ncolors at the same time.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>What is near\ninfrared imaging used for?<\/li><\/ul>\n\n\n\n<p>Near-infrared spectroscopy and imaging uses near-infrared\nlight between 650 and 950 nm to non-invasively detect the concentration and\noxygenation of hemoglobin in the brain, muscles and other tissues, and is used,\nfor example, to detect changes induced by brain activity, injury, or disease.\nIt has also been widely used by scientists to study anatomical features,\ninternal organs and lymphatic vasculatures, as well as by clinicians to\ndiagnose diseases, locate tumours and assist surgical procedures.<\/p>\n\n\n\n<p>In addition, NIR imaging is a growing field for both\npreclinical and clinical application to the clinical management for cancer\npatients due to its advantageous features, such as detailed molecular profiling\nwith the multiplexed use of fluorescent probes.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>How does\nnear-infrared fluorescence imaging work?<\/li><\/ul>\n\n\n\n<p>NIR fluorescence imaging and tomography involves administration\nof a fluorescent contrast agent that (i) can be excited at wavelengths of 780\nnm or greater, and (ii) has a significant Stoke&#8217;s shift emitting fluorescence\nat wavelengths of 800 nm or greater. <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Where to\nfind contrast agents for Near-Infrared Fluorescent Imaging?<\/li><\/ul>\n\n\n\n<p>Traditional organic NIR contrast agents have the problems\nof fast photobleaching, non-specific protein adsorption and biodegradation.\nThen NIR contrast agents based on inorganic nanoparticles have been extensively\nstudied because of its excellent fluorescence brightness and stability. These\nnanoparticles include semiconductor quantum dots (QD), gold nanoshells, and\ndye-encapsulated nanoparticles.<\/p>\n\n\n\n<p> CD Bioparticles is proficient in nanoparticles preparation and imaging contrast agents development. We provide high quality NIR fluorescent nanoparticles with excellent optical performance and stability. Nanoparticles conjugation services are also available to make multifunctional contrast agents for target-specific imaging, multimodal imaging, as well as simultaneous diagnosis and therapy for your unique requirements.<\/p>\n\n\n\n<p>About the author <\/p>\n\n\n\n<p>CD Bioparticles, a biotech company with years of expertise in diagnosis and imaging contrast agents development, now offers custom NIR fluorescent imaging contrast agents with ideal optical properties. Our experienced scientists can construct both organic and inorganic nanoparticles fluorophores for NIR fluorescent imaging. <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>References<br> Kosaka, N., Ogawa, M., Choyke, P. L., &amp; Kobayashi, H. (2009). Clinical implications of near-infrared fluorescence imaging in cancer. Future oncology, 5(9), 1501-1511.<br> Marshall, M. V., Rasmussen, J. C., Tan, I. C., Aldrich, M. B., Adams, K. E., Wang, X., \u2026 &amp; Sevick-Muraca, E. M. (2010). Near-infrared fluorescence imaging in humans with indocyanine green: a review and update. Open surgical oncology journal (Online), 2(2), 12.<br> Deng, G., Li, S., Sun, Z., Li, W., Zhou, L., Zhang, J., \u2026 &amp; Cai, L. (2018). Near-infrared fluorescence imaging in the largely unexplored window of 900-1,000 nm. Theranostics, 8(15), 4116. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>What is near-infrared fluorescence imaging?&nbsp; Near-infrared (NIR) fluorescence is a light wavelength of 650\u2013950 nm and is generally preferred for<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,2,31],"tags":[83,76,10],"class_list":["post-321","post","type-post","status-publish","format-standard","hentry","category-applications","category-nanoparticles","category-quantum-dots","tag-contrast-agents","tag-gold-nanoshells","tag-quantum-dots"],"_links":{"self":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/comments?post=321"}],"version-history":[{"count":2,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/321\/revisions"}],"predecessor-version":[{"id":327,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/321\/revisions\/327"}],"wp:attachment":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/media?parent=321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/categories?post=321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/tags?post=321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}