{"id":283,"date":"2021-05-31T03:51:46","date_gmt":"2021-05-31T08:51:46","guid":{"rendered":"https:\/\/www.cd-bioparticles.com\/blog\/?p=283"},"modified":"2021-05-31T03:51:46","modified_gmt":"2021-05-31T08:51:46","slug":"what-are-gold-nanoparticles","status":"publish","type":"post","link":"https:\/\/www.cd-bioparticles.com\/blog\/nanoparticles\/what-are-gold-nanoparticles\/","title":{"rendered":"What Are Gold Nanoparticles?"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"491\" src=\"\/blog\/wp-content\/uploads\/2021\/05\/Gold-nanoparticle-and-diagnostics-1024x491.jpg\" alt=\"\" class=\"wp-image-284\" srcset=\"\/blog\/wp-content\/uploads\/2021\/05\/Gold-nanoparticle-and-diagnostics-1024x491.jpg 1024w, \/blog\/wp-content\/uploads\/2021\/05\/Gold-nanoparticle-and-diagnostics-300x144.jpg 300w, \/blog\/wp-content\/uploads\/2021\/05\/Gold-nanoparticle-and-diagnostics-768x368.jpg 768w, \/blog\/wp-content\/uploads\/2021\/05\/Gold-nanoparticle-and-diagnostics.jpg 1269w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><a href=\"https:\/\/www.cd-bioparticles.com\/product\/gold-nanorods-list-165.html\">Gold nanoparticles<\/a> (AuNPs) are\nsmall gold particles with a diameter of 1 to 100 nm. Once dispersed in water,\nAuNPs are also known as colloidal gold. <\/p>\n\n\n\n<p><strong>What are gold nanoparticles used for?<\/strong><\/p>\n\n\n\n<p>AuNPs have been widely applied in bionanotechnology due to\ntheir unique properties and multiple surface functionalities. The ease of AuNP\nfunctionalization provides a versatile platform for nanobiological assemblies\nwith oligonucleotides, antibodies, and proteins. Bioconjugates of AuNPs have\nalso become promising candidates in the design of novel biomaterials for the\ninvestigation of biological systems.<\/p>\n\n\n\n<p>The versatility of AuNPs has provided useful materials for\na range of biomedical applications. In diagnostics, the binding event between\nthe analytes and the AuNPs can alter the physicochemical properties of AuNPs\nsuch as surface plasmon resonance, conductivity, and redox behavior, leading to\ndetectable signals. AuNPs also serve as practical platforms for therapeutic\nagents, with their high surface area allowing a dense presentation of multifunctional\nmoieties (e.g., drugs and targeting agents). <\/p>\n\n\n\n<p><strong>How are gold nanoparticles made?<\/strong><\/p>\n\n\n\n<p>A wide array of solution-based approaches has been\ndeveloped in the past few decades to control the size, shape, and surface\nfunctionality.&nbsp;Turkevich&nbsp;<em>et al.<\/em> developed a synthetic method\nfor creating AuNPs in 1951 by treating hydrogen tetrachloroaurate (HAuCl4) with\ncitric acid in boiling water, where the citrate acts as both reducing and\nstabilizing agent. Frens further refined this method by changing the gold-to-citrate\nratio to control particle size.&nbsp;This protocol has been widely employed to\nprepare to dilute solutions of moderately stable spherical AuNPs with diameters\nof 10 to 20 nm, though larger AuNPs (e.g., 100 nm) can also be prepared.&nbsp;<\/p>\n\n\n\n<p>In a standard experiment, gold <a href=\"https:\/\/www.cd-bioparticles.com\/product\/nanoparticles-list-4.html\">nanoparticles<\/a> were\nsynthesized according to the procedure described by Turkevich <em>et al.<\/em>, that\nis chemical reduction of the gold precursor HAuCl4 by dissolved trisodium\ncitrate at 75 \u00b0C from aqueous solutions containing 0.25 and 2.5 mmol\/L of gold\nprecursor and citrate, respectively.<\/p>\n\n\n\n<p><strong>How can you tell gold nanoparticles? <\/strong><\/p>\n\n\n\n<p>Colorimetry is a solution-based assay method that by\nmeasuring the absorption wavelength, can estimate the concentration of the\nmaterial in the solution, and according to the specific properties of the gold\nnanoparticles, based on these particles colorimetry can be a suitable candidate\nfor detection in these particles.<\/p>\n\n\n\n<p><strong>Are gold nanoparticles toxic?<\/strong><\/p>\n\n\n\n<p>Even though, it is generally accepted that plain gold\nnanoparticles are toxic both <em>in vitro<\/em> and <em>in vivo<\/em> in certain\nrange of concentrations. With proper surface modifications, the toxic effect\ncan be reduced or even eliminated.<\/p>\n\n\n\n<p>About the author<\/p>\n\n\n\n<p>As a leading manufacturer and supplier of various nanoparticles, CD Bioparticles offers a comprehensive list of coated, functional and conjugated <a href=\"https:\/\/www.cd-bioparticles.com\/product\/spherical-gold-nanoparticles-list-164.html\">gold nanoparticles<\/a> by precisely surface engineering. We provide gold nanoparticles functionalized with active groups such as NHS, carboxyl, amine, and hydroxyl. And conjugated nanoparticles with a variety of biological ligands are available for your unique requirements.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>References<br> Yeh, Y. C., Creran, B., &amp; Rotello, V. M. (2012). Gold nanoparticles: preparation, properties, and applications in bionanotechnology. Nanoscale, 4(6), 1871-1880.<br> Polte, J., Ahner, T. T., Delissen, F., Sokolov, S., Emmerling, F., Thu\u0308nemann, A. F., &amp; Kraehnert, R. (2010). Mechanism of gold nanoparticle formation in the classical citrate synthesis method derived from coupled in situ XANES and SAXS evaluation. Journal of the American Chemical Society, 132(4), 1296-1301.<br> Jia, Y. P., Ma, B. Y., Wei, X. W., &amp; Qian, Z. Y. (2017). The in vitro and in vivo toxicity of gold nanoparticles. Chinese Chemical Letters, 28(4), 691-702.<br> Jazayeri, M. H., Aghaie, T., Avan, A., Vatankhah, A., &amp; Ghaffari, M. R. S. (2018). Colorimetric detection based on gold nano particles (GNPs): An easy, fast, inexpensive, low-cost and short time method in detection of analytes (protein, DNA, and ion). Sensing and bio-sensing research, 20, 1-8. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Gold nanoparticles (AuNPs) are small gold particles with a diameter of 1 to 100 nm. Once dispersed in water, AuNPs<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[8],"class_list":["post-283","post","type-post","status-publish","format-standard","hentry","category-nanoparticles","tag-gold-nanoparticles"],"_links":{"self":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/283","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/comments?post=283"}],"version-history":[{"count":1,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/283\/revisions"}],"predecessor-version":[{"id":285,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/283\/revisions\/285"}],"wp:attachment":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/media?parent=283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/categories?post=283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/tags?post=283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}