{"id":273,"date":"2021-04-21T00:49:56","date_gmt":"2021-04-21T05:49:56","guid":{"rendered":"https:\/\/www.cd-bioparticles.com\/blog\/?p=273"},"modified":"2021-04-21T00:49:56","modified_gmt":"2021-04-21T05:49:56","slug":"gold-nanoparticles-help-uncover-amyloid-fibrils","status":"publish","type":"post","link":"https:\/\/www.cd-bioparticles.com\/blog\/nanoparticles\/gold-nanoparticles-help-uncover-amyloid-fibrils\/","title":{"rendered":"Gold Nanoparticles Help Uncover Amyloid Fibrils"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/blog\/wp-content\/uploads\/2021\/04\/Gold-Nanoparticles-Help-Uncover-Amyloid-Fibrils-1024x683.jpg\" alt=\"\" class=\"wp-image-274\" srcset=\"\/blog\/wp-content\/uploads\/2021\/04\/Gold-Nanoparticles-Help-Uncover-Amyloid-Fibrils-1024x683.jpg 1024w, \/blog\/wp-content\/uploads\/2021\/04\/Gold-Nanoparticles-Help-Uncover-Amyloid-Fibrils-300x200.jpg 300w, \/blog\/wp-content\/uploads\/2021\/04\/Gold-Nanoparticles-Help-Uncover-Amyloid-Fibrils-768x512.jpg 768w, \/blog\/wp-content\/uploads\/2021\/04\/Gold-Nanoparticles-Help-Uncover-Amyloid-Fibrils-120x80.jpg 120w, \/blog\/wp-content\/uploads\/2021\/04\/Gold-Nanoparticles-Help-Uncover-Amyloid-Fibrils.jpg 1903w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<p>A team of scientists from the Swiss Federal Institute of Technology in Lausanne (EPFL) and collaborators from the University of Ulm in Germany, the University of Modena and the University of Reggio Emilia in Italy, and the Massachusetts Institute of Technology have developed custom nanoparticles for high-resolution detection of amyloid fibrils, which are related to Alzheimer&#8217;s disease and Parkinson&#8217;s disease. The newly developed technology helps researchers to study specific fibril structures in amyloid diseases patients, allowing rapid and high-resolution imaging of fibrils. This breakthrough paper was published in <em>PNAS<\/em> onMarch 24, 2021, titled <em>Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM<\/em>.<\/p>\n\n\n\n<p>One of the characteristics of Alzheimer&#8217;s disease is the\npresence of nodular structures between brain cells, which are called amyloid\nfibrils. These are formed from the notorious amyloid beta peptide and Tau\nprotein, which are two of the most sought-after targets in the development of\ntherapies for the treatment of Alzheimer&#8217;s and similar diseases. Beta amyloid\nand Tau protein are usually produced in the brain. However, these proteins can\nbegin to entangle with each other, forming a huge fibril structure. When this\nhappens, they can cause diseases such as Alzheimer&#8217;s disease and other\nneurodegenerative diseases.<\/p>\n\n\n\n<p>Increasing evidence suggests that amyloid polymorphism\ngives rise to different strains of amyloids with distinct toxicities and\npathology-spreading properties. Validating this hypothesis is challenging due\nto a lack of tools and methods that allow for the direct characterization of\namyloid polymorphism in hydrated and complex biological samples. In this study,\nthe research team describes nanoparticles (NPs) that efficiently label amyloid\nfibrils produced<em> in vitro<\/em> or isolated from postmortem tissues, under\nhydrating conditions and in such a way as to unmask their polymorphism and\nmorphological features. Using these NPs, the researchers show that pathological\naggregates exhibit exceptional morphological homogeneity compared with amyloid\nfibrils produced <em>in vitro<\/em>, consistent with the emerging view that the\nphysiologic milieu is a key determinant of amyloid fibril strains. <\/p>\n\n\n\n<p>These finding results should not only facilitate the profiling\nand characterization of amyloids for structural studies by cryo-EM, but also\npave the way to elucidate the structural basis of amyloid strains and toxicity,\nand possibly the correlation between the pathological and clinical\nheterogeneity of amyloid diseases. The team also expressed that the\nnanoparticles are powerful and desperately needed tools for rapid imaging and\nprofiling of amyloid morphological polymorphism in different types of samples\nunder cryo-conditions, especially complex samples isolated from human-derived\npathological aggregates.<\/p>\n\n\n\n<p>About the author As a leading manufacturer and supplier of various nanoparticles, CD Bioparticles offers a comprehensive list of coated, functional and conjugated <a href=\"https:\/\/www.cd-bioparticles.com\/product\/spherical-gold-nanoparticles-list-164.html\">gold nanoparticles<\/a> by precise surface engineering. We provide gold nanoparticles functionalized with active groups such as NHS, carboxyl, amine and hydroxyl. And conjugated nanoparticles with a variety of biological ligands are available for your unique requirements. <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>References<br> Cendrowska, U., Silva, P. J., Ait-Bouziad, N., M\u00fcller, M., Guven, Z. P., Vieweg, S., \u2026 &amp; Lashuel, H. A. (2020). Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM. Proceedings of the National Academy of Sciences, 117(12), 6866-6874.<br> Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne. (2020, March 12). Gold nanoparticles uncover amyloid fibrils. ScienceDaily. Retrieved March 28, 2021. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>A team of scientists from the Swiss Federal Institute of Technology in Lausanne (EPFL) and collaborators from the University of<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,2],"tags":[74,8],"class_list":["post-273","post","type-post","status-publish","format-standard","hentry","category-applications","category-nanoparticles","tag-amyloid-fibrils","tag-gold-nanoparticles"],"_links":{"self":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/273","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/comments?post=273"}],"version-history":[{"count":1,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/273\/revisions"}],"predecessor-version":[{"id":275,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/273\/revisions\/275"}],"wp:attachment":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/media?parent=273"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/categories?post=273"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/tags?post=273"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}