{"id":260,"date":"2021-03-20T01:55:53","date_gmt":"2021-03-20T06:55:53","guid":{"rendered":"https:\/\/www.cd-bioparticles.com\/blog\/?p=260"},"modified":"2021-03-20T01:55:53","modified_gmt":"2021-03-20T06:55:53","slug":"researchers-learn-that-non-toxic-concentration-of-silver-nanoparticles-can-antagonize-arsenic-induced-genotoxicity","status":"publish","type":"post","link":"https:\/\/www.cd-bioparticles.com\/blog\/nanoparticles\/researchers-learn-that-non-toxic-concentration-of-silver-nanoparticles-can-antagonize-arsenic-induced-genotoxicity\/","title":{"rendered":"Researchers Learn That Non-toxic Concentration of Silver Nanoparticles Can Antagonize Arsenic-induced Genotoxicity"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"479\" src=\"\/blog\/wp-content\/uploads\/2021\/03\/Silver-nanoparticles-Can-Antagonize-Arsenic-induced-Genotoxicity-1024x479.jpg\" alt=\"\" class=\"wp-image-261\" srcset=\"\/blog\/wp-content\/uploads\/2021\/03\/Silver-nanoparticles-Can-Antagonize-Arsenic-induced-Genotoxicity-1024x479.jpg 1024w, \/blog\/wp-content\/uploads\/2021\/03\/Silver-nanoparticles-Can-Antagonize-Arsenic-induced-Genotoxicity-300x140.jpg 300w, \/blog\/wp-content\/uploads\/2021\/03\/Silver-nanoparticles-Can-Antagonize-Arsenic-induced-Genotoxicity-768x359.jpg 768w, \/blog\/wp-content\/uploads\/2021\/03\/Silver-nanoparticles-Can-Antagonize-Arsenic-induced-Genotoxicity.jpg 1269w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<p>Recently, a research team found that non-toxic\nconcentrations of silver nanoparticles can antagonize the genotoxicity induced\nby arsenic by reducing the bioaccumulation of heavy metal arsenic in mammalian\ncells and enhancing the anti-oxidant ability in the cells. Related research\nresults were published in Journal of <em>Hazardous Materials<\/em> with the title\nof <em>Silver nanoparticles protect against arsenic induced genotoxicity via\nattenuating arsenic bioaccumulation and elevating antioxidation in mammalian\ncells<\/em>.<\/p>\n\n\n\n<p>Arsenic is one of the most toxic inorganic pollutants in\nthe environment. In 2012, the International Agency for Research on Cancer\nlisted arsenic and its compounds as Class I carcinogens. At present, the\ncommonly used antidote for arsenic poisoning in clinics are dimercaptopropanol,\nsodium dimercaptopropanesulfonate, sodium dimercaptobutane disodium, etc.\nHowever, these non-specific antidotes usually have toxic side effects in\ntreatment. Therefore, there is an urgent need to develop a novel, safe and\nefficient method to reduce the harm of arsenic to organisms.<\/p>\n\n\n\n<p>This new study aimed to investigate the protective effects\nof silver nanoparticles (AgNPs) at non-toxic concentrations on As(\u2162) induced\ngenotoxicity and the underlying mechanism. The research data showed that AgNPs\npretreatment significantly inhibited the generation of phosphorylated histone\nH2AX (\u03b3-H2AX, marker of nuclear DNA double strand breaks) and the mutation\nfrequencies induced by As(\u2162) exposure.<\/p>\n\n\n\n<p>Atomic fluorescence spectrometer (AFS) and laser ablation-inductively\ncoupled plasma-mass spectrometry (LA-ICP-MS) analysis revealed that the\nintracellular accumulation of As(\u2162) in human-hamster hybrid AL cells was\ndeclined by AgNPs via suppressing the expression of specific As(\u2162)-binding\nprotein (Gal-1). Moreover, the activities of antioxidant enzymes were greatly\nup-regulated by AgNPs, which eventually inhibited the generation of reactive\noxygen species (ROS) induced by As(\u2162) and the downstream stress-activated\nprotein kinases\/c-Jun amino-terminal kinases (SAPK\/JNK) signaling pathway.<\/p>\n\n\n\n<p>These results provided clear evidence that AgNPs\ndramatically suppressed the genotoxic response of As(\u2162) in mammalian cells via\ndecreasing As(\u2162) bioaccumulation and elevating intracellular antioxidation,\nwhich might provide a new clue for AgNPs applications in As(\u2162) detoxification.<\/p>\n\n\n\n<p>About the author<\/p>\n\n\n\n<p>Nanoparticles have various uses in biomedical applications; they can act as anticancer diagnostic agents by targeting, sensing, and imaging as well as drug delivery systems in conjunction with photodynamic therapy. Engineered silver nanoparticles (AgNPs) have received a great deal of attention in mechanosensitive-based chemotherapies, immunotherapies, drug delivery mechanisms, and nanomedicine.  As a leading manufacturer and supplier of various nanoparticles, CD Bioparticles provides a comprehensive list of <a href=\"https:\/\/www.cd-bioparticles.com\/product\/silver-nanoparticles-list-166.html\">silver nanoparticles<\/a> with different surface properties in multiple sizes. Silver nanoparticles produced with our proprietary protocols are highly monodisperse with a narrow size distribution, and can be applied in the nanotoxicology research, sensor Development, Metal-Enhanced Fluorescence (MEF), Surface Enhance Raman Spectroscopy (SERS), and Dark Field Microscopy. <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>References<br> Wang, X., Nie, Y., Si, B., Wang, T., Hei, T. K., Du, H., \u2026 &amp; Liu, Y. (2021). Silver nanoparticles protect against arsenic induced genotoxicity via attenuating arsenic bioaccumulation and elevating antioxidation in mammalian cells. Journal of Hazardous Materials, 125287.<br> Raja, G., Jang, Y. K., Suh, J. S., Kim, H. S., Ahn, S. H., &amp; Kim, T. J. (2020). Microcellular environmental regulation of silver nanoparticles in cancer therapy: A critical review. Cancers, 12(3), 664. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Recently, a research team found that non-toxic concentrations of silver nanoparticles can antagonize the genotoxicity induced by arsenic by reducing<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,2],"tags":[71,12],"class_list":["post-260","post","type-post","status-publish","format-standard","hentry","category-applications","category-nanoparticles","tag-genotoxicity","tag-silver-nanoparticles"],"_links":{"self":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/comments?post=260"}],"version-history":[{"count":1,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/260\/revisions"}],"predecessor-version":[{"id":262,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/260\/revisions\/262"}],"wp:attachment":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/media?parent=260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/categories?post=260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/tags?post=260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}