{"id":257,"date":"2021-03-20T01:52:10","date_gmt":"2021-03-20T06:52:10","guid":{"rendered":"https:\/\/www.cd-bioparticles.com\/blog\/?p=257"},"modified":"2021-03-20T01:52:10","modified_gmt":"2021-03-20T06:52:10","slug":"advances-in-research-on-iron-oxide-nanoparticles-to-amplify-tumor-imaging-signals","status":"publish","type":"post","link":"https:\/\/www.cd-bioparticles.com\/blog\/magnetic-beads\/advances-in-research-on-iron-oxide-nanoparticles-to-amplify-tumor-imaging-signals\/","title":{"rendered":"Advances in Research on Iron Oxide Nanoparticles to Amplify Tumor Imaging Signals"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"\/blog\/wp-content\/uploads\/2021\/03\/Iron-Oxide-Nanoparticles-to-Amplify-Tumor-Imaging-Signals-1024x683.jpg\" alt=\"\" class=\"wp-image-258\" srcset=\"\/blog\/wp-content\/uploads\/2021\/03\/Iron-Oxide-Nanoparticles-to-Amplify-Tumor-Imaging-Signals-1024x683.jpg 1024w, \/blog\/wp-content\/uploads\/2021\/03\/Iron-Oxide-Nanoparticles-to-Amplify-Tumor-Imaging-Signals-300x200.jpg 300w, \/blog\/wp-content\/uploads\/2021\/03\/Iron-Oxide-Nanoparticles-to-Amplify-Tumor-Imaging-Signals-768x512.jpg 768w, \/blog\/wp-content\/uploads\/2021\/03\/Iron-Oxide-Nanoparticles-to-Amplify-Tumor-Imaging-Signals-120x80.jpg 120w, \/blog\/wp-content\/uploads\/2021\/03\/Iron-Oxide-Nanoparticles-to-Amplify-Tumor-Imaging-Signals.jpg 1269w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<p>Iron oxide nanoparticles have high stability, good\ndispersion, simple preparation and good biocompatibility. They have shown a\nwide range of application prospects in the fields of sensor detection, disease\ndiagnosis, gene therapy vectors, and targeted drug delivery. Recently, a\nresearch team has made progress in the use of hypoxia-assembled ultra-small\niron oxide nanoparticles to amplify the fluorescence and magnetic resonance\nimaging signals of tumors. Relevant research results titled <em>Hypoxia-Triggered\nSelf-Assembly of Ultrasmall Iron Oxide Nanoparticles to Amplify the Imaging\nSignal of a Tumor<\/em> are available on <em>Journal of the American Chemical\nSociety<\/em>.<\/p>\n\n\n\n<p>Hypoxia is common in solid tumors and has an important\nimpact on tumor occurrence, development, metastasis, and treatment tolerance.\nIt can be used as a separate indicator of treatment prognosis. Therefore,\npredicting and evaluating the degree of hypoxia in tumor patients plays an\nimportant role in the evaluation of treatment effects and the choice of treatment\nmethods. However, the hypoxic zone is located in the tumor far away from the\nblood vessel. Traditional contrast agents are not easy to enrich and stay in\nthis area for a long time, which creates obstacles to the imaging of this area.\nThis phenomenon puts forward higher design requirements for the permeability of\nnano-contrast materials.<\/p>\n\n\n\n<p>In this study, the researchers developed a novel hypoxia\nimaging probe, consisting of a hypoxia-triggered self-assembling ultrasmall\niron oxide (UIO) nanoparticle and assembly-responding fluorescence dyes (NBD),\nto provide dual-mode imaging <em>in vivo<\/em>. And the team employed\nnitroimidazole derivatives as the hypoxia-sensitive moiety to construct\nintermolecular cross-linking of UIO nanoparticles under hypoxia, which\nirreversibly forms larger nanoparticle assemblies. The hypoxia-triggered\nperformance of UIO self-assembly not only amplifies its T2-weighted MRI signal\nbut also promotes the fluorescence intensity of NBD through its emerging\nhydrophobic environment incorporated into self-assemblies. <em>In vivo<\/em>\nresults further confirm that our hypoxic imaging probe can display a prompt MRI\nsignal for the tumor interior region, and its signal enhancement performs a\nlong-term effective feature and gradually reaches 3.69 times amplification. Simultaneously,\nthis probe also exhibits obvious green fluorescence in the hypoxic region of\ntumor sections.<\/p>\n\n\n\n<p>Accordingly, the researcher also has developed an MRI\ndifference value method to visualize the 3D distribution and describe the\nextent of the hypoxic tumor region within the whole body of mice. Due to its\nnotable efficiency of penetration and accumulation inside a hypoxic tumor, the\nhypoxia imaging probe could also be considered as a potential candidate as a\nversatile platform for hypoxia-targeted drug delivery, and meanwhile its\nhypoxia-related therapeutic efficacy can be monitored.<\/p>\n\n\n\n<p>About the author CD Bioparticles is committed to providing a large and increasing portfolio of magnetic nanoparticles to meet any research needs. We now offer a series of <a href=\"https:\/\/www.cd-bioparticles.com\/product\/iron-oxide-nanorods-list-261.html\">Iron Oxide Nanorods<\/a> (non-magnetic) with rod-shaped structure to meet our customers\u2019 multiple requirements. These iron oxide nanorods have strong light resistance, and are non-toxic, tasteless, insoluble in alkali and slightly soluble in acid, and can be widely used in coatings, plastics, paints and pharmaceutical fields. <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Reference<br> Zhou, H., Guo, M., Li, J., Qin, F., Wang, Y., Liu, T., \u2026 &amp; Chen, C. (2021). Hypoxia-Triggered Self-Assembly of Ultrasmall Iron Oxide Nanoparticles to Amplify the Imaging Signal of a Tumor. Journal of the American Chemical Society, 143(4), 1846-1853. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Iron oxide nanoparticles have high stability, good dispersion, simple preparation and good biocompatibility. They have shown a wide range of<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,6],"tags":[70,16],"class_list":["post-257","post","type-post","status-publish","format-standard","hentry","category-applications","category-magnetic-beads","tag-iron-oxide-nanoparticles","tag-tumor"],"_links":{"self":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/comments?post=257"}],"version-history":[{"count":1,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/257\/revisions"}],"predecessor-version":[{"id":259,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/257\/revisions\/259"}],"wp:attachment":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/media?parent=257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/categories?post=257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/tags?post=257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}