{"id":253,"date":"2021-02-08T02:30:26","date_gmt":"2021-02-08T07:30:26","guid":{"rendered":"https:\/\/www.cd-bioparticles.com\/blog\/?p=253"},"modified":"2021-02-08T02:30:26","modified_gmt":"2021-02-08T07:30:26","slug":"what-are-upconverting-nanoparticles","status":"publish","type":"post","link":"https:\/\/www.cd-bioparticles.com\/blog\/upconverting-nanoparticles\/what-are-upconverting-nanoparticles\/","title":{"rendered":"What Are Upconverting Nanoparticles?"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"950\" height=\"596\" src=\"\/blog\/wp-content\/uploads\/2021\/02\/NaYF4-Structure-Upconverting-Nanoparticles.png\" alt=\"\" class=\"wp-image-254\" srcset=\"\/blog\/wp-content\/uploads\/2021\/02\/NaYF4-Structure-Upconverting-Nanoparticles.png 950w, \/blog\/wp-content\/uploads\/2021\/02\/NaYF4-Structure-Upconverting-Nanoparticles-300x188.png 300w, \/blog\/wp-content\/uploads\/2021\/02\/NaYF4-Structure-Upconverting-Nanoparticles-768x482.png 768w\" sizes=\"auto, (max-width: 950px) 100vw, 950px\" \/><\/figure><\/div>\n\n\n\n<p>Upconverting nanoparticles (UCNPs) are nanoscale particles, with diameter from 1nm to 100 nm that can exhibit photon upconversion. Since Fran\u00e7ois formally proposed the concept of upconversion luminescence in 1966, to the introduction of nanotechnology in the 1990s, scientists have synthesized many new functional inorganic <a href=\"https:\/\/www.cd-bioparticles.com\/product\/upconverting-nanoparticles-list-170.html\">upconversion nanoparticles<\/a> with water solubility and high luminous efficiency. This functional upconversion nanomaterial has promoted the development of the diagnosis, treatment, imaging, and biological monitoring in the field of biomedicine. <\/p>\n\n\n\n<p><strong>Applications of upconverting nanoparticles<\/strong><\/p>\n\n\n\n<p>Due to UCNPs\u2019 unique photophysical properties, including\nlight-emitting stability, excellent upconversion luminescence efficiency, low\nautofluorescence, and high detection sensitivity, and high penetration depth in\nsamples, UCNPs have been widely applied in biomedical applications, such as\nbiosensing, imaging and theranostics.<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Bioimaging<\/li><\/ol>\n\n\n\n<p>As an important technology in modern medical diagnosis,\nbio-fluorescence imaging has attracted much attention. Since the organism\nitself cannot provide fluorescent information for diagnosis, it is necessary to\ndevelop bio-fluorescence probes for bio-fluorescence imaging. Traditional\nbio-fluorescence probes mainly include organic dyes and quantum dots. In recent\nyears, UCNPs have the advantages of good light stability, low detection limit\nof <em>in vivo<\/em> imaging, high signal-to-noise ratio and large penetration depth,\nmaking them more ideal biomarkers than organic dyes and quantum dots, but there\nare also shortcomings such as single imaging mode, weak luminescence of rare-earth\nions, and energy backflow between the photosensitizer Er3+ and the activator.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Photodynamic therapy<\/li><\/ul>\n\n\n\n<p>Photodynamic therapy (PDT) refers to an emerging technology for the diagnosis and treatment of diseases that uses photodynamic effects. In PDT treatment technology, the photosensitizer and its excitation light are the key elements. The excitation light source must have the spectrum and energy that the photosensitizer can absorb, as well as a certain degree of tissue penetration. However, the traditional excitation light cannot fully penetrate the tissue. PDT is only suitable for shallow tumors, but not for deep tumors, which greatly limits the scope of clinical application of PDT. The emergence of UCNPs makes it possible for PDT to use near-infrared light and other tissue-penetrating light sources as excitation light. This overcomes the shortcomings and limitations of traditional PDT technology that cannot fully penetrate tissues, improves the therapeutic effect of PDT, and broadens its clinical application range.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Therapeutics<\/li><\/ul>\n\n\n\n<p>How to learn about the tumor treatment status in real-time\nwhile performing treatment, so as to adjust the treatment method is a hot\nresearch topic in recent years. UCNPs themselves are also a kind of fluorescent\nmaterials, which can provide high-sensitivity optical imaging. Utilizing the\nnatural optical imaging potential of UCNPs and the realization of multi-mode\nimaging by doping with a variety of lanthanide ions with imaging potential, it\nhas unparalleled advantages for timely improvement of drug tracking during\ntreatment.<\/p>\n\n\n\n<p>About the author<\/p>\n\n\n\n<p>CD Bioparticles provides a comprehensive list of upconverting nanoparticles with different surface ligands as well as variable emission range. Our upconverting nanoparticles can either be oil or water dispersible. By precise surface modification, upconverting nanoparticles are available with coated, amine functionalized and antibody conjugated forms. These photoluminescent nanoparticles can be used for bio-imaging, molecular recognition and photodynamic therapy.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Reference<br>Liang, G., Wang, H., Shi, H., Wang, H., Zhu, M., Jing, A., &#8230; &amp; Li, G. (2020). Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment.<em> Journal of Nanobiotechnology<\/em>, 18(1), 1-22. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Upconverting nanoparticles (UCNPs) are nanoscale particles, with diameter from 1nm to 100 nm that can exhibit photon upconversion. Since Fran\u00e7ois<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[69],"class_list":["post-253","post","type-post","status-publish","format-standard","hentry","category-upconverting-nanoparticles","tag-upconversion-nanoparticles"],"_links":{"self":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/253","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/comments?post=253"}],"version-history":[{"count":1,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/253\/revisions"}],"predecessor-version":[{"id":255,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/253\/revisions\/255"}],"wp:attachment":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/media?parent=253"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/categories?post=253"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/tags?post=253"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}