{"id":250,"date":"2021-02-08T02:09:32","date_gmt":"2021-02-08T07:09:32","guid":{"rendered":"https:\/\/www.cd-bioparticles.com\/blog\/?p=250"},"modified":"2021-02-08T02:09:32","modified_gmt":"2021-02-08T07:09:32","slug":"mosaic-nanoparticles-elicit-cross-reactive-immune-responses-to-zoonotic-coronaviruses-in-mice","status":"publish","type":"post","link":"https:\/\/www.cd-bioparticles.com\/blog\/nanoparticles\/mosaic-nanoparticles-elicit-cross-reactive-immune-responses-to-zoonotic-coronaviruses-in-mice\/","title":{"rendered":"Mosaic Nanoparticles Elicit Cross-reactive Immune Responses to Zoonotic Coronaviruses in Mice"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"827\" src=\"\/blog\/wp-content\/uploads\/2021\/02\/Construction-of-RBD-Nanoparticles-1024x827.jpg\" alt=\"\" class=\"wp-image-251\" srcset=\"\/blog\/wp-content\/uploads\/2021\/02\/Construction-of-RBD-Nanoparticles-1024x827.jpg 1024w, \/blog\/wp-content\/uploads\/2021\/02\/Construction-of-RBD-Nanoparticles-300x242.jpg 300w, \/blog\/wp-content\/uploads\/2021\/02\/Construction-of-RBD-Nanoparticles-768x620.jpg 768w, \/blog\/wp-content\/uploads\/2021\/02\/Construction-of-RBD-Nanoparticles.jpg 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<p>SARS-CoV-2, a newly-emergent betacoronavirus that caused a\nglobal pandemic in 2020, is just one of many different viruses in the\ncoronavirus family. Many members of this virus family circulate in animal\npopulations such as bats, and may infect humans like SARS-CoV-2. There is an\nurgent need for protection against SARS-CoV-2 and SARS-related emergent\nzoonotic coronaviruses. <\/p>\n\n\n\n<p>Researchers in the laboratory of Pamela Bj\u00f6rkman, the David\nBaltimore Professor of Biology and Bioengineering are working on developing\nvaccines against a series of related coronaviruses with the purpose of\npreventing future pandemics. And now a research team, led by graduate student\nAlex Cohen in the Bj\u00f6rkman lab, has designed a protein-based 60-subunit\nnanoparticle with fragments of up to 8 different types of coronavirus attached\nto it. When injected into mice, the vaccine induces antibodies that respond to\na variety of coronaviruses, including similar viruses that are not present on\nthe nanoparticles. The relevant research results were published online in the\njournal <em>Science<\/em> on January 12, 2021, with a tittle <em>Mosaic nanoparticles\nelicit cross-reactive immune responses to zoonotic coronaviruses in mice<\/em>.<\/p>\n\n\n\n<p>In this study, these researchers made homotypic\nnanoparticles displaying the receptor-binding domain (RBD) of SARS-CoV-2 or\nco-displaying SARS-CoV-2 RBD along with RBDs from animal betacoronaviruses that\nrepresent threats to humans (mosaic nanoparticles; 4-8 distinct RBDs). Mice\nimmunized with RBD-nanoparticles, but not soluble antigen, elicited\ncross-reactive binding and neutralization responses. Mosaic-RBD-nanoparticles elicited\nantibodies with superior cross-reactive recognition of heterologous RBDs\ncompared to sera from immunizations with homotypic SARS-CoV-2\u2013RBD-nanoparticles\nor COVID-19 convalescent human plasmas. Moreover, sera from\nmosaic-RBD\u2013immunized mice neutralized heterologous pseudotyped coronaviruses\nequivalently or better after priming than sera from homotypic\nSARS-CoV-2\u2013RBD-nanoparticle immunizations, demonstrating no immunogenicity loss\nagainst particular RBDs resulting from co-display. <\/p>\n\n\n\n<p>The researchers believe that a single immunization with\nmosaic-RBD-nanoparticles provides a potential strategy to simultaneously\nprotect against SARS-CoV-2 and emerging zoonotic coronaviruses. Professor\nBj\u00f6rkman also expressed that these results indicate that it is possible to\nimprove diverse neutralizing antibody responses, even for coronavirus strains\nthat are not present on the injectable nanoparticles. They hope that this\ntechnology can be used to prevent animal coronaviruses from crossing into\nhumans in the future. In addition, they also think the nanoparticles can also\ncause a neutralizing response to SARS-CoV-2, so it is possible to use them to\nprevent COVID-19 and other coronaviruses with pandemic potential.<\/p>\n\n\n\n<p>About the author: With years of experience in the pharmaceutical and life science sector, CD Bioparticles is a leading manufacturer and supplier of various <a href=\"https:\/\/www.cd-bioparticles.com\/product\/nanoparticles-list-4.html\">nanoparticles<\/a> that can be widely used in biology and medicine fields, including colloidal gold nanoparticles, silver nanoparticles, silica nanoparticles, titania nanoparticles, inorganic fluorescent nanoparticles (quantum dots and upconverting nanocrystals), and biodegradable polymer nanoparticles. Our nanoparticles are manufactured with different shapes and sizes, and the particle surface can be coated, functionalized or conjugated with biomolecules for research use. <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p> References<br>1. Cohen, A. A., Gnanapragasam, P. N., Lee, Y. E., Hoffman, P. R., Ou, S., Kakutani, L. M., &#8230; &amp; Bjorkman, P. J. (2021). Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice. <em>Science<\/em>.<br>2. California Institute of Technology. &#8220;Nanoparticle immunization technology could protect against many strains of coronaviruses: Method presents the immune system with several different coronaviruses at once.&#8221; ScienceDaily. ScienceDaily, 12 January 2021. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>SARS-CoV-2, a newly-emergent betacoronavirus that caused a global pandemic in 2020, is just one of many different viruses in the<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[5,59],"class_list":["post-250","post","type-post","status-publish","format-standard","hentry","category-nanoparticles","tag-nanoparticles","tag-sars-cov-2"],"_links":{"self":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/comments?post=250"}],"version-history":[{"count":1,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/250\/revisions"}],"predecessor-version":[{"id":252,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/250\/revisions\/252"}],"wp:attachment":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/media?parent=250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/categories?post=250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/tags?post=250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}