{"id":207,"date":"2020-11-05T00:41:31","date_gmt":"2020-11-05T05:41:31","guid":{"rendered":"https:\/\/www.cd-bioparticles.com\/blog\/?p=207"},"modified":"2020-11-05T00:41:31","modified_gmt":"2020-11-05T05:41:31","slug":"pnas-decoy-nanoparticles-protect-against-covid-19-by-concurrently-adsorbing-viruses-and-inflammatory-cytokines","status":"publish","type":"post","link":"https:\/\/www.cd-bioparticles.com\/blog\/applications\/pnas-decoy-nanoparticles-protect-against-covid-19-by-concurrently-adsorbing-viruses-and-inflammatory-cytokines\/","title":{"rendered":"PNAS: Decoy Nanoparticles Protect against COVID-19 by Concurrently Adsorbing Viruses and Inflammatory Cytokines"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"\/blog\/wp-content\/uploads\/2020\/11\/PNAS-Decoy-Nanoparticles-Protect-against-COVID-19-by-Concurrently-Adsorbing-Viruses-and-Inflammatory-Cytokines-1-1024x576.jpg\" alt=\"\" class=\"wp-image-208\" srcset=\"\/blog\/wp-content\/uploads\/2020\/11\/PNAS-Decoy-Nanoparticles-Protect-against-COVID-19-by-Concurrently-Adsorbing-Viruses-and-Inflammatory-Cytokines-1-1024x576.jpg 1024w, \/blog\/wp-content\/uploads\/2020\/11\/PNAS-Decoy-Nanoparticles-Protect-against-COVID-19-by-Concurrently-Adsorbing-Viruses-and-Inflammatory-Cytokines-1-300x169.jpg 300w, \/blog\/wp-content\/uploads\/2020\/11\/PNAS-Decoy-Nanoparticles-Protect-against-COVID-19-by-Concurrently-Adsorbing-Viruses-and-Inflammatory-Cytokines-1-768x432.jpg 768w, \/blog\/wp-content\/uploads\/2020\/11\/PNAS-Decoy-Nanoparticles-Protect-against-COVID-19-by-Concurrently-Adsorbing-Viruses-and-Inflammatory-Cytokines-1.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<p>As of October 15, 216,025 deaths from COVID-19 have been\nreported in the United States, and more than 840,000 deaths globally have been\ncaused by the COVID-19 pandemic from SARS-COV-2 infection. Unfortunately, there\nis currently no licensed vaccine or specific treatment. Over the past few\nmonths, scientists have pulled out all the tricks to develop treatments for\nCOVID-19, from stem cells and synthetic antibodies to common over-the-counter\ndrugs and proven steroids. Effective treatments for COVID-19 are urgently\nneeded all over the world.<\/p>\n\n\n\n<p>Now, in a new study, researchers at Fudan University in\nChina, Wuhan University, Jinan University and the National Institutes of Health\n(NIH) in the United States reported a decoy nanoparticle against COVID-19.\nAccording to their research, they\u2019ve made it through a powerful two-step\nneutralization approach:<\/p>\n\n\n\n<p>\u201cvirus neutralization in the first step followed by\ncytokine neutralization in the second step. The nanodecoy, made by fusing\ncellular membrane nanovesicles derived from human monocytes and genetically\nengineered cells stably expressing angiotensin converting enzyme II (ACE2)\nreceptors, possesses an antigenic exterior the same as source cells. By\ncompeting with host cells for virus binding, these nanodecoys effectively protect\nhost cells from the infection of pseudoviruses and authentic SARS-CoV-2.\nMoreover, relying on abundant cytokine receptors on the surface, the nanodecoys\nefficiently bind and neutralize inflammatory cytokines including interleukin 6\n(IL-6) and granulocyte\u2212macrophage colony-stimulating factor (GM-CSF), and\nsignificantly suppress immune disorder and lung injury in an acute pneumonia\nmouse model.\u201d <\/p>\n\n\n\n<p>The authors suggested that their finding could be a\npotential therapeutic method for COVID-19, as their work presents a simple,\nsafe, and robust antiviral nanotechnology. This new finding could provide a new\nstrategy for the design of COVID-19 treatment, but the researchers also pointed\nout further studies and optimization will be necessary before such nanoparticles\ncan be used to fight COVID-19. Related research results were published in <em>PNAS<\/em>\njournal recently, paper entitled <em>Decoy nanoparticles protect against\nCOVID-19 by concurrently adsorbing viruses and inflammatory cytokines<\/em>.&nbsp; <\/p>\n\n\n\n<p>It is not difficult to find that this study proposed a\nnovel drug design idea for the prevention and control of COVID-19 infection.\nWhile interfering with viral infection, it also neutralized and verified\ncytokines, so as to further alleviate immune disorders caused by cytokine\nstorm. At the same time, this nano-bait particle has a broad spectrum of\ncoronavirus neutralization effect, can resist a variety of coronavirus using\nACE2 as the invasion receptor, and has no biological toxicity, providing a\nunique solution for the novel coronavirus drug design.<\/p>\n\n\n\n<p>About the author: CD Bioparticles is a global leading manufacturer and supplier of various <a href=\"https:\/\/www.cd-bioparticles.com\/\">nanoparticles<\/a>, microparticles and their coatings for R&amp;D and commercialization in a wide variety of application areas including <em>in vitro<\/em> diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. It provides highly uniform nanoparticles widely used in biology and medicine, including colloidal gold nanoparticles, silver nanoparticles, silica nanoparticles, titania nanoparticles, inorganic fluorescent nanoparticles (quantum dots and upconversion nanocrystals), as well as biodegradable polymer nanoparticles.  <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Reference:<br>Rao, L., Xia, S., Xu, W., Tian, R., Yu, G., Gu, C., \u2026 &amp; Lu, L. (2020). Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines. Proceedings of the National Academy of Sciences. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>As of October 15, 216,025 deaths from COVID-19 have been reported in the United States, and more than 840,000 deaths<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[30,5],"class_list":["post-207","post","type-post","status-publish","format-standard","hentry","category-applications","tag-covid-19","tag-nanoparticles"],"_links":{"self":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/207","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/comments?post=207"}],"version-history":[{"count":1,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/207\/revisions"}],"predecessor-version":[{"id":209,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/207\/revisions\/209"}],"wp:attachment":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/media?parent=207"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/categories?post=207"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/tags?post=207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}