{"id":150,"date":"2020-05-08T21:17:58","date_gmt":"2020-05-09T02:17:58","guid":{"rendered":"https:\/\/www.cd-bioparticles.com\/blog\/?p=150"},"modified":"2020-05-08T21:17:58","modified_gmt":"2020-05-09T02:17:58","slug":"a-universal-flu-vaccine-developed-using-novel-nanoparticles","status":"publish","type":"post","link":"https:\/\/www.cd-bioparticles.com\/blog\/nanoparticles\/a-universal-flu-vaccine-developed-using-novel-nanoparticles\/","title":{"rendered":"A Universal Flu Vaccine Developed Using Novel Nanoparticles"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"702\" src=\"\/blog\/wp-content\/uploads\/2020\/05\/A-Universal-Flu-Vaccine-Developed-Using-Novel-Nano-1-1024x702.png\" alt=\"\" class=\"wp-image-151\" srcset=\"\/blog\/wp-content\/uploads\/2020\/05\/A-Universal-Flu-Vaccine-Developed-Using-Novel-Nano-1-1024x702.png 1024w, \/blog\/wp-content\/uploads\/2020\/05\/A-Universal-Flu-Vaccine-Developed-Using-Novel-Nano-1-300x206.png 300w, \/blog\/wp-content\/uploads\/2020\/05\/A-Universal-Flu-Vaccine-Developed-Using-Novel-Nano-1-768x527.png 768w, \/blog\/wp-content\/uploads\/2020\/05\/A-Universal-Flu-Vaccine-Developed-Using-Novel-Nano-1.png 1532w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<p>A new study by the Institute for Biomedical Sciences,\nGeorgia State University, has shown that a novel nanoparticle-vaccine that\ncombines two major influenza proteins can effectively provide mice with broad\nand long-lasting protection against influenza viruses, suggesting it has hope\nto be a universal influenza vaccine for humans. This finding is published in\nthe journal <em>Advanced Healthcare Materials<\/em>.<\/p>\n\n\n\n<p>The influenza virus proteins, matrix protein 2\nextracellular domain (M2e) and neuraminidase (NA) made up the double-layered\nnano-vaccine. Before being exposed to influenza viruses, mice were immunized\nwith nano-vaccines and protected against six different virus strains. The\nresult has shown that such unique combination of vaccines has the possibility\nto be used as universal influenza vaccines or as an ingredient in such\nvaccines.<\/p>\n\n\n\n<p>Ye Wang, Ph.D., the first author of the study working in\nDr. Bao-Zhong Wang\u2019s lab in the Institute for Biomedical Sciences, expressed\nthat this combination of nanoparticle antigens provides powerful\ncross-protection for mice, and it protects mice from different strains of\ninfluenza virus. He said each season there are different strains of influenza\nvirus to affect people, and hope this nanoparticle vaccine can protect humans\nfrom different strains of the flu virus by using this method.&nbsp; <\/p>\n\n\n\n<p>Influenza is an infectious respiratory disease caused by\ninfluenza viruses, which is the main cause of death from infection. Seasonal\ninfluenza vaccines are not enough to prevent influenza outbreaks, so the\ndevelopment of universal influenza vaccines is an ideal strategy to address the\nthreat to public health from influenza and pandemics. The universal influenza\nvaccine will eliminate the need for vaccination in each season and provide\nuniversal protection against all influenza strains.<\/p>\n\n\n\n<p>The influenza virus protein M2e has been found in all\ninfluenza virus strains, each with a very similar version, and the protein\nmutates very slowly over time. The NA protein is found on the surface of\ninfluenza virus, and its mutation is much slower than that of other influenza\nproteins. This double-layered nanoparticle vaccine has M2e as the core and NA\ncovering the surface.<\/p>\n\n\n\n<p>In this study, mice received the nanoparticle vaccine\nthrough intramuscular injection and were exposed to one of six influenza virus\nstrains. Facts have proved that the vaccine has long-lasting immune protection,\nand even four months after immunization, it has not changed against virus\nattacks.<\/p>\n\n\n\n<p>Co-author of the study, Gilbert Gonzalez, laboratory manager of Dr. Bao-Zhong Wang\u2019s laboratory at the Institute for Biomedical Sciences believes that it is critical to note that many influenza vaccines have not targeted NA before, which has become a more and more important antigen in influenza vaccine research. In the past, because hemagglutinin (HA) dominated, NA has been ignored and underestimated.  When people are infected with influenza, the body will react to HA. But the HA protein mutates very rapidly, that\u2019s why scientists must change seasonal influenza vaccines every year. People may be infected with the flu this year and be immune to this specific HA protein, but by the next flu season, the HA protein will change rapidly and people will no longer be protected. Next, the researchers expressed that they would plan to inoculate this double-layered nano-vaccine onto a microneedle patch for skin vaccination. <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Reference:<br>Wang, Y., Deng, L., Gonzalez, G. X., Luthra, L., Dong, C., Ma, Y., &#8230; &amp; Wang, B. Z. (2020). Double\u2010Layered M2e\u2010NA Protein Nanoparticle Immunization Induces Broad Cross\u2010Protection against Different Influenza Viruses in Mice. <em>Advanced healthcare materials<\/em>, 9(2), 1901176. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>A new study by the Institute for Biomedical Sciences, Georgia State University, has shown that a novel nanoparticle-vaccine that combines<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,2],"tags":[39,38],"class_list":["post-150","post","type-post","status-publish","format-standard","hentry","category-applications","category-nanoparticles","tag-influenza-virus","tag-vaccine"],"_links":{"self":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/comments?post=150"}],"version-history":[{"count":1,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/150\/revisions"}],"predecessor-version":[{"id":152,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/150\/revisions\/152"}],"wp:attachment":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/media?parent=150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/categories?post=150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/tags?post=150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}