{"id":121,"date":"2020-03-31T01:37:31","date_gmt":"2020-03-31T06:37:31","guid":{"rendered":"https:\/\/www.cd-bioparticles.com\/blog\/?p=121"},"modified":"2020-03-31T01:37:31","modified_gmt":"2020-03-31T06:37:31","slug":"what-happens-to-magnetic-nanoparticles-in-human-stem-cells","status":"publish","type":"post","link":"https:\/\/www.cd-bioparticles.com\/blog\/magnetic-beads\/what-happens-to-magnetic-nanoparticles-in-human-stem-cells\/","title":{"rendered":"What Happens to Magnetic Nanoparticles in Human Stem Cells?"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"\/blog\/wp-content\/uploads\/2020\/03\/What-Happens-to-Magnetic-Nanoparticles-in-Human-Stem-Cells-1-1024x768.jpg\" alt=\"\" class=\"wp-image-122\" srcset=\"\/blog\/wp-content\/uploads\/2020\/03\/What-Happens-to-Magnetic-Nanoparticles-in-Human-Stem-Cells-1-1024x768.jpg 1024w, \/blog\/wp-content\/uploads\/2020\/03\/What-Happens-to-Magnetic-Nanoparticles-in-Human-Stem-Cells-1-300x225.jpg 300w, \/blog\/wp-content\/uploads\/2020\/03\/What-Happens-to-Magnetic-Nanoparticles-in-Human-Stem-Cells-1-768x576.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<p>Although magnetic nanoparticles have been increasingly used\nin cell imaging and tissue bioengineering, the changes that have taken place\nwithin stem cells in the long-term have not been revealed. A recent study from\nCNRS, the Sorbonne University, and universities Paris Diderot and Paris 13, has\nshown that these nanoparticles undergo significant degradation inside the stem\ncells, and in some cases, the cells &#8220;remagnetize&#8221;. The results were\npublished on PNAS, which may explain the existence of &#8220;natural&#8221;\nmagnetism in human cells and help to develop new tools for nanomedicine, due to\nthis magnetism generated by the cells themselves.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.cd-bioparticles.com\/product\/magnetic-particles-list-1.html\">Magnetic nanoparticles<\/a> are at the\ncore of today&#8217;s nanomedicine: they act as imaging diagnosis agents, thermal\nanticancer agents, drug targeting agents and tissue engineering agents. After\ncompleting the therapeutic task, their fate in cells has not been well\nunderstood.<\/p>\n\n\n\n<p>To track the journey of these nanoparticles through the\ncells, scientists from CNRS\/University of Diderot and the INSERM\/University of\nParis Diderot\/University of Paris 13, collaborated with researchers at Sorbonne\nUniversity and together conducted the intensive research. Previously,\nresearchers have developed a primitive approach to nanomagnetism in biological\nsystems: first, they incorporated magnetic nanoparticles into human stem cells<em>\nin vitro<\/em>. Then researchers\nlet them differentiate and develop for a month, observing them in the\nintracellular environment for a long time, and monitoring their transformation.<\/p>\n\n\n\n<p>By tracking the &#8220;magnetic fingerprints&#8221; of these\nnanoparticles in cells, researchers have demonstrated that they are first\ndestroyed (decreased cell magnetization) and release iron into the\nintracellular environment. Next, this &#8220;free&#8221; iron is stored in\nnon-magnetic form in ferritin, which is responsible for storing iron or served\nas the basis for the biosynthesis of new magnetic nanoparticles in the cell.<\/p>\n\n\n\n<p>This phenomenon is known to occur in some bacteria, but this biosynthesis has never been shown in mammalian cells. This could explain the magnetic crystals are present in the human body, which are observed in cells of different organs, especially the brain. What&#8217;s more, this magnetic iron storage could also be a way for cells to &#8220;detoxify&#8221; against the excess iron for a long time. From a nanomedicine perspective, this biosynthesis opens up a new avenue for the possibility of purely biological magnetic marking in cells. CD Bioparticles provides highly uniform nanoparticles for biology and medicine research uses, including colloidal gold nanoparticles, <a href=\"https:\/\/www.cd-bioparticles.com\/product\/silver-nanoparticles-list-166.html\">silver nanoparticles<\/a>, silica nanoparticles, <a href=\"https:\/\/www.cd-bioparticles.com\/product\/titania-nanoparticles-list-171.html\">titania nanoparticles<\/a>, inorganic fluorescent nanoparticles (quantum dots and upconversion nanocrystals), and biodegradable polymer nanoparticles. These nanoparticles are manufactured with different shapes and sizes, and the particle surface can be coated, functionalized or conjugated with biomolecules. Scientists focus on the fields of immunoassay, bioseparation, medical imaging and diagnosis, as well as drug delivery and cancer therapy can find more available nanoparticles at CD Bioparticles. <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Reference\uff1a<br>Van de Walle, A., Sangnier, A. P., Abou-Hassan, A., Curcio, A., Hemadi, M., Menguy, N., &#8230; &amp; Wilhelm, C. (2019). Biosynthesis of magnetic nanoparticles from nano-degradation products revealed in human stem cells.<em> Proceedings of the National Academy of Sciences<\/em>, 116(10), 4044-4053. <\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Although magnetic nanoparticles have been increasingly used in cell imaging and tissue bioengineering, the changes that have taken place within<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,6],"tags":[4,12,27],"class_list":["post-121","post","type-post","status-publish","format-standard","hentry","category-applications","category-magnetic-beads","tag-magnetic-particles","tag-silver-nanoparticles","tag-stem-cells"],"_links":{"self":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/comments?post=121"}],"version-history":[{"count":1,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/121\/revisions"}],"predecessor-version":[{"id":123,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/posts\/121\/revisions\/123"}],"wp:attachment":[{"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/media?parent=121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/categories?post=121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cd-bioparticles.com\/blog\/wp-json\/wp\/v2\/tags?post=121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}